Giant Bombcast

You don't listen so much as get absorbed into a world of killer helicopters, non-sequiters, bizarre drinks, explosive cans of fish and man sized spiders. Beyond all that you have accessible gaming chat that never seems to devolve into the overly pretentious posturing which goes on in most big gaming podcasts. These guys aren't looking to discuss the deeper issues of games, just the ones that affect real gamers. Essential listening.